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Xinyong Liu Selected Research

autosomal dominant Spastic paraplegia 6

8/2022Chemical space exploration around indolylarylsulfone scaffold led to a novel class of highly active HIV-1 NNRTIs with spiro structural features.
3/2021Exploiting the tolerant region I of the non-nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket. Part 2: Discovery of diarylpyrimidine derivatives as potent HIV-1 NNRTIs with high Fsp3 values and favorable drug-like properties.
10/2020Fsp3: A new parameter for drug-likeness.

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Xinyong Liu Research Topics

Disease

16Infections
01/2022 - 02/2010
15Human Influenza (Influenza)
12/2021 - 10/2011
8Acquired Immunodeficiency Syndrome (AIDS)
12/2021 - 10/2008
7Neoplasms (Cancer)
01/2022 - 02/2014
4COVID-19
02/2022 - 11/2020
4Virus Diseases (Viral Diseases)
01/2022 - 01/2011
4HIV Infections (HIV Infection)
04/2016 - 01/2009
3Hyperuricemia
10/2022 - 11/2019
3Gout
10/2022 - 09/2017
3autosomal dominant Spastic paraplegia 6
08/2022 - 10/2020
3Brain Ischemia (Cerebral Ischemia)
03/2015 - 01/2013
2Vesicular Stomatitis
01/2022 - 12/2020
2Hepatitis B
11/2020 - 09/2020
2Alzheimer Disease (Alzheimer's Disease)
01/2019 - 01/2018
2Drug-Related Side Effects and Adverse Reactions
01/2018 - 01/2010
2Infarction (Infarctions)
03/2015 - 01/2013
2Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
03/2015 - 01/2013
2Reperfusion Injury
03/2015 - 01/2013
2Ischemia
01/2014 - 01/2013
1Sepsis (Septicemia)
06/2022
1Neoplasm Metastasis (Metastasis)
01/2022
1Liver Neoplasms (Liver Cancer)
01/2022
1Liver Diseases (Liver Disease)
04/2021
1Intracranial Thrombosis (Cerebral Thrombosis)
03/2018
1Coronary Disease (Coronary Heart Disease)
03/2018
1Angina Pectoris
03/2018
1Parkinson Disease (Parkinson's Disease)
04/2017
1Ebola Hemorrhagic Fever
01/2017
1Vaccinia
11/2016
1Cardiovascular Diseases (Cardiovascular Disease)
10/2015
1Mitochondrial Diseases (Mitochondrial Disease)
07/2014
1Myeloid Leukemia (Leukemia, Myelocytic)
02/2014

Drug/Important Bio-Agent (IBA)

18Pharmaceutical PreparationsIBA
10/2022 - 07/2009
14Antiviral Agents (Antivirals)IBA
01/2022 - 01/2010
7Oseltamivir (Tamiflu)FDA Link
12/2021 - 10/2014
7tetramethylpyrazineIBA
03/2018 - 01/2013
6Neuraminidase (Sialidase)IBA
12/2021 - 10/2014
4Uric Acid (Urate)IBA
10/2022 - 09/2017
4Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2011
4Anti-HIV Agents (AIDS Drugs)IBA
01/2018 - 10/2008
4CXC 195IBA
04/2017 - 01/2013
3lesinuradIBA
10/2022 - 09/2017
3EndonucleasesIBA
02/2019 - 11/2017
3NucleosidesIBA
01/2011 - 02/2010
2Poly I-CIBA
01/2022 - 12/2020
2CarbonIBA
03/2021 - 10/2020
2InterferonsIBA
12/2020 - 11/2020
2VaccinesIBA
11/2020 - 01/2017
2oseltamivir carboxylateIBA
02/2020 - 06/2012
2ButyrylcholinesteraseIBA
01/2019 - 01/2018
2PiperazineIBA
07/2018 - 02/2014
2Amantadine (Aman)FDA LinkGeneric
10/2015 - 06/2012
2Ribavirin (Virazole)FDA LinkGeneric
10/2015 - 06/2012
2RimantadineFDA LinkGeneric
10/2015 - 06/2012
2AntioxidantsIBA
01/2014 - 01/2013
2Reverse Transcriptase InhibitorsIBA
01/2011 - 09/2010
1Uricosuric AgentsIBA
10/2022
1Human immunodeficiency virus 1 reverse transcriptaseIBA
08/2022
1Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
01/2022
1Hormones (Hormone)IBA
01/2022
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
01/2022
1punicalaginIBA
01/2021
1Circular DNAIBA
11/2020
1BenzbromaroneIBA
10/2020
1urate transporterIBA
10/2020
1A-Form DNA (A-DNA)IBA
09/2020
1cdc25 PhosphatasesIBA
09/2020
13- (5- nitrofuryl)- 7- (5- nitrofurfurylidene)- 3,3a,4,5,6,7- hexahydro- 2H- indazoleIBA
05/2020
1chebulagic acidIBA
01/2020
1chebulinic acidIBA
01/2020
1Phosphoprotein Phosphatases (Phosphatases, Protein)IBA
12/2019
1AnionsIBA
11/2019
1AdamantaneIBA
07/2018
1nasIBA
07/2018
1DipeptidesIBA
07/2018
1RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA
01/2018
1AcetylcholinesteraseIBA
01/2018
1Carrier Proteins (Binding Protein)IBA
09/2017
1SaltsIBA
09/2017
1favipiravirIBA
01/2017
1QuinazolinesIBA
11/2016
1Cidofovir (Vistide)FDA Link
11/2016
1Biological ProductsIBA
11/2016
1PurinesIBA
10/2015
1piperidineIBA
10/2015
1Glucose (Dextrose)FDA LinkGeneric
03/2015
1WortmanninIBA
03/2015
1Oxygen (Dioxygen)IBA
03/2015
1Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA
03/2015
1TankyrasesIBA
11/2014
1EnzymesIBA
07/2014
11- (3,4- dihydroxyphenyl)- 2- ((1- mesityl- 1H- imidazo(4,5- c)pyridin- 2- yl)thio)ethanoneIBA
07/2014

Therapy/Procedure

12Therapeutics
02/2022 - 01/2011
4Highly Active Antiretroviral Therapy (HAART)
11/2017 - 01/2009
2Drug Therapy (Chemotherapy)
01/2009 - 10/2008
1Punctures
06/2022
1Ligation
06/2022
1Radiofrequency Ablation
01/2022
1Traditional Medicine (Folk Remedies)
03/2018
1Oral Administration
07/2014